Effect of Costus speciosus and Wedelia chinensis on Brain Neurotransmitters and Enzyme Monoamine Oxidase Following Cold Immobilization Stress
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چکیده
22 Effect of Costus speciosus and Wedelia chinensis on Brain Neurotransmitters and Enzyme Monoamine Oxidase Following Cold Immobilization Stress Nitin Verma * and R .L. Khosa Pharmacognosy and Phytochemistry Division, Department of Pharmacy, Bharat Institute of Technology, Partapure Bypass Road Meerut250103, U.P. India ______________________________________________________________________________________ ABSTRACT: The effect of alcoholic extracts of Costus speciosus rhizomes and Wedelia chinensis leaves were evaluated on stress induced changes in brain neurotransmitters and enzyme monoamine oxidase levels in albino rats. The extracts were found to possess normalizing activity against cold immobilization stress induced changes in norepinephrine (NE), dopamine (DA), 5-hydroxy tryptamine (5-HT), 5-hydroxy indole acetic acid (5HIAA), and enzyme monoamine oxidase (MAO), The results obtained provide biochemical evidence for antistress activity of the tested extracts.
منابع مشابه
CNS Drug Reviews
Monoamine oxidase (MAO) is an enzyme that metabolizes a wide range of monoamines and is important in the control of the concentration of these neurotransmitters. Several reports have shown that stress can decrease MAO inhibitory activity. An endogenous MAO inhibitory component was first discovered in normal human urine by Glover et al. (22), and the compound responsible for the MAO activity was...
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